Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder.
نویسندگان
چکیده
A patient with a lifelong bleeding disorder is presented with a prolonged bleeding time and abnormal aggregation and secretion responses to arachidonic acid, thromboxane A2, PAF-acether and the divalent calcium ionophore A23187. Platelet alpha and dense granule contents and morphology appear normal. The proposed defect is due to an abnormality of a platelet intracellular calcium dependent process.
منابع مشابه
Impaired platelet response to thromboxane-A2 and defective calcium mobilization in a patient with a bleeding disorder.
Platelet aggregation, secretion, and thromboxane formation induced by various agonists, including arachidonate, prostaglandin-G2 (PGG2), and thromboxane-A2 (TxA2), were examined in a patient with a bleeding disorder who was previously reported to have a TxA2-related defect. Aggregation and 14C-5HT secretion were decreased, and no TxB2 formation occurred in response to adenosine diphosphate (ADP...
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ورودعنوان ژورنال:
- Journal of clinical pathology
دوره 36 10 شماره
صفحات -
تاریخ انتشار 1983